2. Signaling Pathways
  3. GPCR/G Protein
  4. Orphan Receptor

Orphan Receptor

 

Orphan Receptor Related Products (42):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1058
    Benfluorex hydrochloride
    		99.96%
    Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.
    Benfluorex hydrochloride
  • HY-149164
    BTB09089
    		Agonist 99.43%
    BTB09089 is a T cell death-associated gene 8 (TDAG8/GPR65) specific agonist. BTB09089 increases TDAG8 expression and regulates the cytokine production of T cells and macrophages.
    BTB09089
  • HY-115613
    ML-180
    		Agonist 99.06%
    ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM). ML-180 has the potential for LRH-1-dependent cancers.
    ML-180
  • HY-108469
    BI-6015
    		Antagonist 99.44%
    BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BI6015 represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes.
    BI-6015
  • HY-P1342
    Prosaptide Tx14(A)
    		Agonist 98.84%
    Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells.
    Prosaptide Tx14(A)
  • HY-109568
    Lynestrenol
    		Agonist 99.87%
    Lynestrenol is a pregnane X receptor (PXR) agonist with the EC50s of 41 and 0.23 μM for hPXR and zfPXR, respectively. Lynestrenol, a synthetic progesteronelike agent possess immunostimulatory properties.
    Lynestrenol
  • HY-109869
    Photoregulin1
    		Modulator
    Photoregulin1 is a compound with the potential to inhibit retinitis pigmentosa that modulates gene expression in retinal cells and slows the degeneration of photoreceptors in a mouse model.
    Photoregulin1
  • HY-118054
    LRH-1 Inhibitor-3
    		Inhibitor
    LRH-1 Inhibitor-3 is a small molecule that inhibits LRH-1 transcriptional activity, thereby decreasing the expression of target genes associated with cell growth and proliferation. LRH-1 Inhibitor-3 has shown potential in reducing cancer cell proliferation in human pancreatic, colon, and breast adenocarcinoma cell lines. LRH-1 Inhibitor-3 serves as a molecular probe for investigating the role of LRH-1 in various malignancies.
    LRH-1 Inhibitor-3
  • HY-160187
    AAA
    		98.4%
    AAA is a potent blocker of 20-Hydroxyeicosatetraenoic acid (20-HETE) receptor that binds directly to GPR75 and prevents the increases in intracellular Ca2+, IP-1 and β-arrestin.
    AAA
  • HY-101483
    Dihydromunduletone
    		Antagonist 99.96%
    Dihydromunduletone (DHM) is a rotenoid derivative and a selective, potent adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonist with an IC 50 of 20.9 μM for GPR56, but not inhibit GPR110 or class A GPCRs.
    Dihydromunduletone
  • HY-12664
    AF64394
    		Agonist 98.01%
    AF64394 is a GPR3 inverse agonist, with a pIC50 of 7.3.
    AF64394
  • HY-131445B
    RR-RJW100
    		Control
    RR-RJW100, the enantiomer of RJW100, is an nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1) agonist. RJW100 can be synthesized as two enantiomers, RR-RJW100 and SS-RJW100, with RR-RJW100 shown to be the more potent LRH-1 agonist. RR-RJW100 is involved in the regulation of metabolic homeostasis and is used in studies of diabetes, liver disease and inflammatory bowel disease.
    RR-RJW100
  • HY-15603
    TS-011
    		Inhibitor 99.28%
    TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.
    TS-011
  • HY-149913
    NR2F1 agonist 1
    		Agonist 99.83%
    NR2F1 agonist 1, a nuclear receptor NR2F1 agonist, specifically activates dormancy programs in malignant cells. NR2F1 agonist 1 up-regulates NR2F1 and downstream target genes that regulate dormancy. NR2F1 agonist 1 induces neural crest-like and growth suppression in head and neck squamous cell carcinoma (HNSCC) via NR2F1 activation. NR2F1 agonist 1 inhibits tumor growth in a mouse primary tumor model.
    NR2F1 agonist 1
  • HY-156354
    GPR61 Inverse agonist 1
    		Agonist 99.33%
    GPR61 Inverse agonist 1 (Compound 1) is a GPR61 inverse agonist (IC50: 11 nM). GPR61 Inverse agonist 1 can be used for research of disorders of metabolism and body weight, such as obesity and cachexia.
    GPR61 Inverse agonist 1
  • HY-155318A
    GPR3 agonist-2
    		Agonist 98.80%
    GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC50of 260 nM.
    GPR3 agonist-2
  • HY-160186
    20-SOLA
    		Inhibitor 98.76%
    20-SOLA is the first water soluble and orally active 20-HETE antagonist. 20-SOLA greatly ameliorates changes in blood pressure and renal injury associated with a streptozotocin (STZ (HY-13753))-diabetic mouse model. 20-SOLA also is a GPR75 receptor blocker. 20-SOLA can be used for the research of cardiovascular pathologies.
    20-SOLA
  • HY-156190A
    NR2F2-IN-1 free base
    		Inhibitor 99.34%
    NR2F2-IN-1 (free base) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 (free base) substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation.
    NR2F2-IN-1 free base
  • HY-155417
    GPR34 receptor antagonist 3
    		Antagonist 99.88%
    GPR34 receptor antagonist 3 (Compound 5e) is a class of GRP34 antagonists, IC50 is 0.680?μM. GPR34 receptor antagonist 3 inhibited ERK1/2 phosphorylation induced by lysophosphatidylserine in a dose-dependent way without obvious cytotoxicity. GPR34 receptor antagonist 3 shows antisensory activity in mouse neuropathic pain model .
    GPR34 receptor antagonist 3
  • HY-135589
    7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene
    		Antagonist 99.77%
    7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene is a liver receptor homolog-1 (LRH-1) antagonist with an IC50 of 3.1 μM.
    7-[4-(2-Piperidinyl)ethoxy]benzoyl Raloxifene